Fabio Luciani

Fabio Luciani

Professor of Systems Immunology, Immunogenomics and Artificial Intelligence

University of New South Wales

Vision of our Lab

Welcome to our multi-disciplinary lab, where we integrate immunology, bioinformatics, AI, and genomics to advance our understanding of autoimmune disorders and cancer. Our vision is to develop a precise cure for autoimmune diseases and cancers, by integrating computational models, artificial intelligence and immunogenomics.

Research Focus

Our lab investigates T cell responses across various contexts:

  • Autoimmune diseases: Coeliac disease, Type 1 diabetes
  • Immunotherapies: CAR T cell therapies, Immuno-checkpoint
  • Ageing

Technologies

To achieve our goals, we utilize:

  • Artificial intelligence to predict immune target
  • Single-cell genomics
  • Bioinformatics
  • Experimental immunology

We invite PhD and Postdocs to join us, engaging in both ‘wet’ (laboratory) and ‘dry’ (computational) projects. PhD Scholarships are available for international candidates, and Summer Research Scholarships for third-year undergraduates.

Meet the Team

Team Leader

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Fabio Luciani

Professor of Systems Immunology, Immunogenomics and Artificial Intelligence

Team Members

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Arman Safavi

PhD student Systems Immunology and Immunogenomics

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Brendan Hughes

PhD student Systems Immunology and Immunogenomics

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Jerome Samir

Post-Doc at Systems Immunology and Immunogenomics

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Martina Bonomi

PhD student Systems Immunology and Immunogenomics

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Vu Pham

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Alumni

  • Simone Rizzetto, now Data Analyst at A-Star Insititute Singapore
  • Raymond Louie, now Lecturer at UNSW
  • David Koppstein, now Group leader at DKTK Heidelberg
  • Lies Boelen, now Senior Data Analyst
  • Preston Leung, Senior postdoc in genomics at Prince of Wales hospital
  • Thiruni Adikari, now postdoc at Oxford
  • Curtis Cai, now postdoc at Karolinska Institutet
  • Chaturaka Rodrigo, now Senior Lecturer at UNSW
  • Neil Bretana, now Data Analyst at University of South Australia

Projects

Publications

Quickly discover relevant content by filtering publications.

The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

Peripheral CD8+ T cell tolerance is a checkpoint in both autoimmune disease and anti-cancer immunity. Despite its importance, the …
Willem Van Der Byl, Simone Nüssing, Timothy J. Peters, Antonio Ahn, Hanjie Li, Guy Ledergor, Eyal David, Andrew S. Koh, Mayura V. Wagle, Christian Deo T. Deguit, Maria N. de Menezes, Avraham Travers, Shienny Sampurno, Kelly M. Ramsbottom, Rui Li, Axel Kallies, Paul A. Beavis, Ralf Jungmann, Maartje M.C. Bastings, Gabrielle T. Belz, Shom Goel, Joseph A. Trapani, Gerald R. Crabtree, Howard Y. Chang, Ido Amit, Chris C. Goodnow, Fabio Luciani, Ian A. Parish
PDF DOI

Discovery of a monoclonal, high-affinity CD8+ T-cell clone following natural hepatitis C virus infection

Heterogeneity of T cells is a hallmark of a successful adaptive immune response, harnessing the vast diversity of antigen-specific T …
Curtis Cai, Elizabeth Keoshkerian, Kristof Wing, Jerome Samir, Manuel Effenberger, Kilian Schober, Rowena A. Bull, Andrew R. Lloyd, Dirk H. Busch, Fabio Luciani
PDF DOI

Expanded T cell clones with lymphoma driver somatic mutations in refractory celiac disease

Intestinal inflammation continues in a subset of celiac disease (CD) patients despite a gluten-free diet. Here, by applying multiomic …
Mandeep Singh, Raymond H. Y. Louie, Jerome Samir, Matthew A. Field, Claire Milthorpe, Thiruni Aldiriki, Joseph Mackie, Ellise Roper, Megan Faulks, Katherine J. L. Jackson, Andrew Calcino, Melinda Y. Hardy, Piers Blombery, Timothy G. Amos, Ira W. Deveson, Scott A. Read, Dmitri Shek, Antoine Guerin, Cindy S. Ma, Stuart G. Tangye, Antonio Di Sabatino, Marco V. Lenti, Alessandra Pasini, Rachele Ciccocioppo, Golo Ahlenstiel, Dan Suan, Jason A. Tye-Din, Christopher C. Goodnow, Fabio Luciani
PDF DOI

CAR+ and CAR− T cells share a differentiation trajectory into an NK-like subset after CD19 CAR T cell infusion in patients with B cell malignancies

Chimeric antigen receptor (CAR) T cell therapy is effective in treating B cell malignancies, but factors influencing the persistence of …
Raymond H. Y. Louie, Curtis Cai, Jerome Samir, Mandeep Singh, Ira W. Deveson, James M. Ferguson, Timothy G. Amos, Helen M. McGuire, Kavitha Gowrishankar, Thiruni Adikari, Robert Balderas, Martina Bonomi, Marco Ruella, David Bishop, David Gottlieb, Emily Blyth, Kenneth Micklethwaite, Fabio Luciani
PDF DOI

Chimeric Antigen Receptor T Cell Therapy Targeting Epithelial Cell Adhesion Molecule in Gastric Cancer: Mechanisms of Tumor Resistance

Epithelial cell adhesion molecule (EpCAM) is a tumor-associated antigen that is frequently overexpressed in various carcinomas. We have …
Yanping Yang, Raymond Louie, Janusz Puc, Yogindra Vedvyas, Yago Alcaina, Irene M. Min, Matt Britz, Fabio Luciani, Moonsoo M. Jin
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News and Updates

Contacts

  • High Street, Kensington Campus, Sydney, NSW 2035